Home Latest news Schnitzler’s syndrome

Schnitzler’s syndrome

by admin
1.6K views

PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled “Schnitzler’s syndrome treated successfully with intravenous pulse cyclophosphamide” (Scand J Rheumatol. 2005 Jul-Aug;34(4):328-30). Authors are Peterlana D, Puccetti A, Tinazzi E et al. from the Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Italy. Schnitzler’s syndrome is a rare clinical condition characterized by chronic urticaria, intermittent fever, bone pain, arthralgia or arthritis, and monoclonal immunoglobulin M (IgM) gammopathy. The authors describe a case of a 48-year-old Italian female with a long history of arthralgia, leucocytosis, spiking fever and chronic urticaria with severe pruritus. The IgM-kappa monoclonal component in the serum and bone densification were detected 4 years after the onset of the symptoms. After many ineffective treatments, the use of pulse cyclophosphamide (CPX) resulted in complete remission of the disease that is still lasting after a 2-year follow-up. To access the abstract of the article, click here.

Related Articles