Medication related osteonecrosis of the jaw (MRONJ) is a serious side effect of anti-resorptive and anti-angiogenic agents. This is a potentially painful and debilitating condition that can significantly affect patients’ quality of life. In this report, we present the case of a 67-year-old female patient who was diagnosed with left breast cancer in 2014. In 2015, bone grafts were detected, and the patient began denosumab and zoledronic acid therapy. After extraction of a tooth in 2016, the bone of the mandible was exposed and osteonecrosis was diagnosed. The patient was admitted to the Clinic of Maxillofacial Surgery for treatment in Plovdiv, where she underwent computed tomography of the lower jaw (CTLM) and then underwent platelet-rich fibrin (PRF) treatment. After hemostasis, PRF was applied and the wound was sutured tightly. The patient was followed up within 1 year and very good results were found with regard to soft tissues and bone at the site of the osteonecrotic lesion. Based on the findings in the literature and in the case described here, it can be concluded that the use of PRF should be considered in the treatment of patients with MRONJ. Read the whole article here.
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