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The 11th National Conference for Rare Diseases and Orphan Drugs, organized by the Institute for Rare Diseases, was held on 11-12 September, 2020. The event was held online for the first year, in a specially developed digital platform – Virtual Congress Venue. The conference presented the new and current trends in the diagnosis, treatment and monitoring of rare diseases, the development of European reference networks and access to innovative technologies. A proceedings book with all presentations and materials presented at the conference are published as a supplement to the scientific journal “Rare Diseases and Orphan Drugs” and can be viewed at the following link.