Hemiplegic migraine is a rare disease and data concerning the pediatric population are even more rare as they are often extrapolated from mixed cohorts.
The aim of this study is to describe a cohort of pediatric patients with genetically confirmed familial hemiplegic migraine (FHM). The knowledge of genotype-phenotype correlations may suggest prognostic factors associated with severe phenotypes.
Patients who met International Classification of Headache Disorders, third edition criteria for FHM, who had a molecular diagnosis, and whose first attack occurred under the age of 18 years are selected.
The study data show that most of the patients with early-onset FHM experience infrequent and non-severe attacks, which improve over time. Furthermore, the clinical course reveals neither the appearance of novel neurological disorders or a deterioration of basic neurological or cognitive functioning. Read the full article here.