Мalignant infantile osteopetrosis

PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled ”Successful unrelated mismatched cord blood transplantation in a child with malignant infantile osteopetrosis.” (Pediatr Transplant. 2006 Aug;10(5):629-31). Authors are Jaing TH, Hou JW, Chen SH et al., from the Division of Hematology/Oncology, Department of Pediatrics, Chang Gung University and Children’s Hospital, Taoyuan, Taiwan. Allogeneic hematopoietic stem cell transplantation represents the only curative option for malignant infantile osteopetrosis (MIOP), a rare disease of infants and young children, characterized by excessive accumulation of mineralized bone and abnormal hematopoiesis. The authors report a case of successful engraftment and stable full-donor chimerism in a patient with MIOP who underwent unrelated donor cord blood transplantation (CBT). A successful engraftment of donor hematopoiesis was demonstrated and the child experienced grade II acute graft vs. host disease (GVHD) involving the skin only. A remarkable but non-progressive decrease in lumbar spine bone mineral density was observed in the first nine months post-transplant. To access the full abstract of the article, click here.