Neurofilament inclusion disease

PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Heterogeneous inclusions in neurofilament inclusion disease” (Neuropathology. 2006 Oct;26(5):417-21). Authors are Uchikado H, Li A, Lin WL et al., from the Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA. Neurofilament inclusion disease (NFID) is a rare disease, whose pathogenesis remains to be elucidated. Immunoreactivity of ubiquitin-binding protein p62 has been reported in various neurodegenerative diseases, but it has not been studied in NFID. In this report the authors show p62 immunoreactivity in neuronal perikaryon of three cases of NFID. They found inclusions in NFID to be heterogenous based on immunoreactivity for alpha-internexin, phosphorylated neurofilament-H, p62 and ubiquitin. The present study extends the list of proteins that have been identified as components of neuronal inclusions in NFID, and may helfor the pathogenesis of NFID. To access the full abstract of the article, click here.