Lhermitte-Duclos disease

PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled “Lhermitte-Duclos disease associated with Cowden syndrome.” (J Clin Neurosci. 2007 May 5). Authors are Tan TC and Ho LC, from the Department of Neurosurgery, Queen Elizabeth Hospital, Kowloon, Hong Kong. Lhermitte-Duclos disease or dysplastic gangliocytoma of the cerebellum, is a rare cerebellar lesion, which can cause mass effects in the posterior fossa. It may occur sporadically, or in association with Cowden syndrome. Cowden syndrome or multiple hamartoma-neoplasia syndrome, is an uncommon autosomal dominant condition characterized by mucocutaneous lesions and systemic malignancies. The authors report two patients with Lhermitte-Duclos disease and associated Cowden syndrome. The clinical, radiological and histopathological features and management strategies of this rare disease complex are discussed. To access the abstract of the article, click here.