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The new issue of “Rare Diseases & Oprhan Drugs” is already published on our website. A new beginning for rare diseases in Bulgaria – this is the main theme of this edition. You can read what happened during the 2nd Balkan Conference for Rare Diseases, what is going on with the regulation of centres of expertise for rare diseases in Bulgaria and what would come after the end of the Bulgarian National Programme for Rare Diseases (2009-2013). We further present you the Rare Diseases Summer School for Health Authorities and Legislators, as well as a review of the rare disease Guillain-Barré syndrome. Have a nice time with “Rare Diseases & Orphan Drugs”.