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A new disease profile is added to our database – Alexander disease (AD). It is an inherited neurodegenerative disorder. AD usually presents in early infancy (0-9 mo) by progressive enlargement of the head, megalencephaly and psychomotor retardation. Other forms that are rarer have also been reported: juvenile and adult forms. GFAP (glial fibrillary acidic protein gene) is the only gene currently associated with Alexander disease. To receive a full description of this rare disease absolutely free of charge, please click here and send us a request The profile was written by our consultant in paediatrics neurology – Dr. Ivan Ivanov, MD, PhD.