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International Conference “Rare Diseases: Europe’s Challenges” will take place on 31st of October 2014 in Rome, Italy. The event is organized by the Italian National Center for Rare Diseases, under the auspices of the Chamber of Deputies, within the framework of the Italian Presidency of the Council of the European Union. The aim of this meeting is to share good practices, identify synergies and concrete modalities for national collaboration and transnational cooperation in order to face and overcome the many challenges posed by rare diseases. For more information or registration, please visit the webpage of the Italian National Centre for Rare Diseases.