Evolution of antiglomerular basement membrane glomerulonephritis into membranous glomerulonephritis

PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Evolution of antiglomerular basement membrane glomerulonephritis into membranous glomerulonephritis. ( Pediatr Nephrol. 2007 Nov 13; ). Authors are Hecht N Omoloja A, Witte D et al., from the Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton, OH, USA. Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare disease characterized by autoantibodies to the alpha 3 chain of type IV collagen in the GBM. It is also known as Goodpasture’s syndrome when associated with pulmonary hemorrhage due to autoantibodies to the alpha 3 chain of type IV collagen also present in pulmonary alveoli. Even more rare is the evolution of anti-GBM GN into membranous nephropathy (MN). We report the management of a 9-year-old Caucasian girl with anti-GBM GN that evolved into MN and briefly review the literature. To access the full abstract of the article, click here.