Functional C1-Inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations

PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Functional C1-Inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations. (J Immunol Methods. 2008 Jul 22.). Authors are Wagenaar-Bos IG Drouet C Aygören-Pursun E et al., from the Department Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema.In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema due to acquired C1-Inh deficiency is reduced C1-Inh function (fC1-Inh).We can recommend the chromogenic assay for the determination of fC1-Inh, while the complex ELISA needs further investigation. To access the full abstract of the article, click here.