Progressive mitral valve thickening and progressive muscle cramps as manifestations of glycogenosis VII

PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Progressive mitral valve thickening and progressive muscle cramps as manifestations of glycogenosis VII (Tarui’s Disease) (Cardiology. 2008;110(4):238-40). Authors are Finsterer J Stöllberger C from the Second Medical Department, and Krankenanstalt Rudolfstiftung, Vienna, Austria. Progressive heart valve thickening and shrinkage, and progressive muscle cramps have not been reported as manifestations of glycogenosis type VII (Tarui’s disease). In a 72-year-old female, Tarui’s disease was diagnosed in 1997, initially manifesting as simple partial seizures since 1977, anginal chest pain since 1982 and muscle cramps since 1983.Progression of Tarui’s disease may manifest as progressive thickening of the heart valves due to glycogen storage. Valve thickening may consecutively lead to valve insufficiency, enlargement of the atrium and atrial fibrillation. Progression of neurological manifestations may manifest as worsening muscle cramps. To access the full abstract of the article, click here.