PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Constant blood flow reduction in premotor frontal lobe regions in ALS with dementia – a SPECT study with 3D-SSP (Acta Neurol Scand. 2007 Nov;116(5):340-4.). Authors are Ishikawa T , Morita M Nakano I et al, from the Division of Neurology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan. We investigated the regional cerebral blood flow in amyotrophic lateral sclerosis with dementia (ALS-D) patients, using single photon emission computed tomography (SPECT). The (123)I-IMP SPECT data for 5 ALS-D and 16 ALS patients were analyzed using three-dimensional stereotactic surface projection (3D-SSP). RESULTS – 3D-SSP demonstrated marked prefrontal hypoperfusion in all the five ALS-D cases and significant bilateral prefrontal hypoperfusion in group comparisons. This study revealed prefrontal hypoperfusion in ALS-D cases to be an obvious abnormality with scientific objectivity. To access the full abstract of the article, click here
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