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The Second Eastern European Conference on Rare Diseases and Orphan Drugs “FOSTERING RESEARCH ON RARE DISEASES IN EASTERN EUROPEAN COUNTRIES” was carried out on 8-9 September 2006 in the beautiful town of Plovdiv (Bulgaria) under the auspices of the Bulgarian Ministry of Health. It was organized by the Information Centre for Rare Diseases and Orphan Drugs – a project of the Bulgarian Association for Promotion of Education and Science.