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The First Eastern European Conference on Rare Diseases and Orphan Drugs, entitled “Promotion of Healthcare and Research on Rare Diseases and Orphan Drugs in Eastern European Countries” took part on 27 May 2005 in the beautiful town of Plovdiv (Bulgaria). It was organized by the Information Centre for Rare Diseases and Orphan Drugs with the official support and partnership of the Bulgarian Ministry of Health and under the auspices of the Mayor of Plovdiv.