PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Unusual warm autoimmune hemolytic anemia in non-alcoholic steatohepatitis (Ann Clin Lab Sci. 2008 Summer;38(3):273-6.). Authors are Boctor FN Gorak E, Prichard JW, et al., from the Division of Laboratory Medicine, Geisinger Medical Center, Danville, USA. Warm autoimmune hemolytic anemia (WAIHA), a rare disease, ranges from an indolent form with mild hemolysis to a life-threatening condition that necessitates transfusion of incompatible red cells. WAIHA can be either idiopathic or secondary to medications or to a lymphoproliferative disorder. We report a case of profound hemolytic anemia in a liver-transplant eligible patient who was diagnosed with cirrhosis secondary to non-alcoholic steatohepatitis (NASH). He developed acute renal failure that required dialysis. Subsequent management included plasmapheresis and rituximab. The patient developed hepatorenal syndrome and died from progressive hepatic failure. To our knowledge, this is the first report of an association between NASH and WAIHA. To access the full abstract of the article, click here.
Publications
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled A case report of malignant sertoli cell tumor (Nippon Hinyokika Gakkai Zasshi. 2008 Jul;99(5):656-9). Authors are Sassa N, Yoshino Y Matsukawa Y et al., from the Nagoya University, Graduate School of Medicine, Department of Urology. Malignant sertoli cell tumor is a rare disease and only a few cases have been described previously. We report a terminal case of malignant sertoli cell tumor. A 38-year-old male visited a hospital with a complaint of swelling his left testis. He underwent high left orchiectomy. After 30 days, he had multiple liver metastases and died 27 months after orchiectomy. All tumor markers were negative in his all clinical courses. To access the full abstract of the article, click here.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Idiopathic nodular glomerulosclerosis: a clinicopathologic study of 15 cases (Hum Pathol. 2008 Aug 11). Authors are Li W Verani RR. from the Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Idiopathic nodular glomerulosclerosis is an enigmatic condition closely resembling diabetic nodular glomerulosclerosis without evidence of diabetic mellitus or other specific disease. Idiopathic nodular glomerulosclerosis remains a rare disease entity with an unclear pathogenesis. Our results confirm previous studies of a close association of hypertension and smoking with idiopathic nodular glomerulosclerosis. A significantly higher incidence of obesity and overweight in patients with idiopathic nodular glomerulosclerosis suggests that increased body mass index may also contribute to the development and progression of idiopathic nodular glomerulosclerosis. To access the full abstract of the article, click here.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Acute abdomen due to twisted ovarian immature teratoma in a 7-year-old girl: magnetic resonance findings with histopathologic correlation. (Pediatr Emerg Care. 2008 Aug;24(8):557-60.). Authors are Boraschi P Donati F Battaglia V. et al., from the 2nd Department of Radiology, Pisa University Hospital, Italy. Immature teratomas represent only the 1% of ovarian teratomas, and they are the third most common primitive germ cell tumor; generally, they are congenital lesions and affect mainly the first 2 decades. We present the case of a 7-year-old child who came at our attention because of an acute low abdominal pain due to the torsion of an ovarian immature grade 1 teratoma on its pedicle. After ultrasound in the emergency department, preoperative evaluation was done by performing a magnetic resonance study, whose findings helped in suggesting the curative approach. The magnetic resonance imaging characteristics of the neoplasm are reviewed and correlated with histopathologic findings. To access the full abstract of the article, click here.
Tetrathiomolybdate – a copper chelator for the treatment of Wilson disease, pulmonary fibrosis and other indications
by admin
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Tetrathiomolybdate, a copper chelator for the treatment of Wilson disease, pulmonary fibrosis and other indications. (IDrugs. 2008 Aug;11(8):592-606.). Authors are Medici V Sturniolo GC from the University of California, Davis, Division of Gastroenterology and Hepatology, Department of Internal Med, Sacramento, CA 95817, USA. Tetrathiomolybdate (TTM) is a copper chelator that has also demonstrated antiangiogenic, antifibrogenic and anti-inflammatory actions in preclinical studies. In a phase III clinical trial, TTM stabilized neurological function in patients with Wilson disease, causing significant recovery in 81% of patients at 3 years post initiation of therapy; a second phase III trial was ongoing at the time of publication. TTM is predicted to most likely find a niche in the therapy of Wilson disease, for which current treatment options are limited. To access the full abstract of the article, click here.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled [A bilateral diaphragmatic paralysis due to Parsonage and Turner syndrome (Rev Pneumol Clin. 2008 Jun;64(3):137-40). Authors are Guinard S Huchot E Couturaud F et al., from the Département de médecine interne et pneumologie, CHRU de la Cavale-Blanche, 5, avenue Foch, 29609 Brest cedex, France. The diaphragmatic paralysis is a rare disease whose causes and evolving forms are numerous. We report the development to eight years of paralysis diaphragmatic bilateral attributed to a Parsonage-Turner syndrome: the lack of recovery is proved by respiratory functional follow-up. The therapeutic possibilities, limited, are discussed. To access the full abstract of the article, click here.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Takotsubo cardiomyopathy in a 68-year old Russian female (Cases J. 2008 Jul 28;1(1):64). Authors are Jayawardena S Sooriabalan D Burzyantseva O et al., from the Dept of Cardiology, Coney Island Hospital, 2601 Ocean Parkway Brooklyn, NY 11235, USA. Takotsubo cardiomyopathy also known as transient left ventricular apical ballooning, stress-induced cardiomyopathy can present with retrosternal chest pain with EKG changes that can mimic a myocardial infraction. We present a 68 female with sudden onset retrosternal squeezing chest pain with positive cardiac enzymes and EKG changes suggestive of acute ST-elevation myocardial infraction. To access the full abstract of the article, click here.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Successful Bilateral Lung Transplantation for Lymphangiomatosis (Am J Transplant. 2008 Jul 28). Authors are Kinnier CV, Eu JP Davis RD et al., from the Division of Pulmonary Medicine, Duke University Medical Center, Durham, NC, USA. Lymphangiomatosis is a rare disease of lymphatic proliferation for which no adequate treatment is known. We report the first successful case of bilateral lung transplantation for the treatment of end-stage pulmonary lymphangiomatosis. A successful outcome was achieved with continued survival beyond 4 years posttransplant and stable lung function. Our report demonstrates that pulmonary lymphangiomatosis should be included among those diseases for which lung transplantation is considered potentially beneficial treatment. To access the full abstract of the article, click here.
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Acute edema blisters in a hereditary angioedema cutaneous attack (Allergol Immunopathol (Madr). 2008 May-Jun;36(3):182-3.). Authors are Fernández Romero D Di Marco P Malbrán A et al., from the Hospital Británico de Buenos Aires. Argentina. Hereditary angioedema is a rare autosomal dominant disease characterized by recurrent episodes of acute edema affecting the skin and the respiratory and digestive tracts. Acute edema blisters or hydro-static bullae develop after rapid accumulation of interstitial fluid usually associated to cardiac insufficiency. Lesions contain sterile fluid and break up easily resolving without scars. Blisters disappear when fluid accumulation resolves. We describe a patient developing recurrent acute edema blisters as a consequence of cutaneous hereditary angioedema attacks. To access the full abstract of the article, click here.
Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients
by admin
PubMed, the Internet portal of biomedical and life sciences literature, indexed an interesting article, entitled Tetrathiomolybdate, a copper chelator for the treatment of Wilson disease, pulmonary fibrosis and other indications. (IDrugs. 2008 Aug;11(8):592-606.). Authors are Medici V Sturniolo GC from the University of California, Davis, Division of Gastroenterology and Hepatology, Department of Internal Med, Sacramento, CA 95817, USA. Tetrathiomolybdate (TTM) is a copper chelator that has also demonstrated antiangiogenic, antifibrogenic and anti-inflammatory actions in preclinical studies. In a phase III clinical trial, TTM stabilized neurological function in patients with Wilson disease, causing significant recovery in 81% of patients at 3 years post initiation of therapy; a second phase III trial was ongoing at the time of publication. TTM is predicted to most likely find a niche in the therapy of Wilson disease, for which current treatment options are limited. To access the full abstract of the article, click here.